As the aesthetics industry continues to evolve, innovative treatments for skin rejuvenation and anti-ageing are rapidly emerging. One of the latest and most exciting developments is the introduction of polynucleotides, a revolutionary approach to skin regeneration and repair. However, while these advanced biostimulatory treatments offer impressive benefits, they are not a direct replacement for dermal fillers. Instead, they serve as a complementary solution for those seeking comprehensive skin health and anti-ageing benefits.
What Are Polynucleotides?
Polynucleotides are derived from highly purified DNA fragments, primarily sourced from fish, that stimulate the skin’s natural repair processes. These biostimulators work at a cellular level to promote tissue regeneration, enhance hydration, and improve skin quality. Unlike traditional dermal fillers, which add volume and contour the face, polynucleotides focus on cellular repair, making them a unique addition to anti-ageing treatments.
How Do They Work?
Polynucleotides exert their effects through several mechanisms:
- Cellular Repair & Regeneration – They stimulate fibroblasts, encouraging collagen and elastin production, leading to firmer, more youthful skin.
- Hydration Boost – Polynucleotides attract water molecules, significantly improving skin hydration and suppleness.
- Antioxidant & Anti-Inflammatory Properties – By reducing oxidative stress and inflammation, they aid in skin healing and prevent premature ageing.
- Improved Skin Texture & Elasticity – Regular treatments lead to smoother, healthier, and more resilient skin.
Polynucleotides vs. Dermal Fillers: What’s the Difference?
One common misconception is that polynucleotides are a replacement for dermal fillers. While both contribute to a more youthful appearance, their functions are fundamentally different.
- Dermal Fillers work by restoring lost volume, contouring facial features, and reducing deep wrinkles by injecting hyaluronic acid or other volumising substances beneath the skin.
- Polynucleotides, on the other hand, do not add volume but work by improving skin quality at a cellular level. They enhance hydration, elasticity, and repair the skin from within, leading to a more natural and long-term rejuvenation effect.
Therefore, while dermal fillers provide immediate volume and structure, polynucleotides work over time to strengthen and regenerate the skin. For those looking for the best anti-ageing outcomes, combining both treatments can offer a synergistic effect, addressing both structure and skin quality.
Why Are Polynucleotides a Must-Have for Anti-Ageing?
The benefits of polynucleotides make them an excellent addition to any aesthetic treatment plan, particularly for individuals looking to improve overall skin health. Key advantages include:
- Natural-Looking Results – Unlike fillers, polynucleotides improve skin texture and elasticity without altering facial volume or structure.
- Long-Term Rejuvenation – Results develop gradually, ensuring progressive and lasting improvement in skin health.
- Versatility – Suitable for a wide range of skin types and areas, including the face, neck, and décolletage.
- Minimal Downtime – Unlike some aesthetic procedures, polynucleotide injections involve minimal recovery time, making them ideal for those with busy lifestyles.
Who Is a Good Candidate for Polynucleotides?
Polynucleotide treatments are ideal for individuals looking to enhance their skin’s quality and combat early signs of ageing. They are particularly beneficial for:
- Those experiencing skin laxity, dehydration, and dullness.
- Individuals seeking a natural approach to anti-ageing without adding volume.
- People wanting to optimise their aesthetic results when used alongside other treatments like fillers, skin boosters, or microneedling.
The Ideal Combination: Polynucleotides & Dermal Fillers
Rather than viewing polynucleotides as an alternative to fillers, the best approach is to combine the two for comprehensive anti-ageing results. Dermal fillers restore lost volume and enhance facial contours, while polynucleotides strengthen the skin’s foundation, improve texture, and boost hydration. Together, they create a more youthful, radiant, and naturally rejuvenated appearance.
Final Thoughts
Polynucleotides represent a cutting-edge advancement in aesthetic medicine, offering unparalleled benefits for skin rejuvenation. While they are not a substitute for dermal fillers, they are an excellent addition to any anti-ageing regimen. By combining polynucleotides with other treatments, individuals can achieve holistic, long-lasting, and natural-looking skin health improvements.
If you’re interested in exploring how polynucleotides can enhance your skincare journey, book a consultation and we will create a personalised treatment plan tailored to your needs. In other cases, more aggressive treatment is needed. There’s no guarantee that the dark spots will fade completely, even with treatment, but an overall improvement is usually possible, sometimes with complete removal achieved.


